Game-Theoretic Models of Bargaining provides a comprehensive picture of the new developments in bargaining theory. It especially shows the way the use of axiomatic models has been complemented by the new results derived from strategic models. The papers in this volume are edited versions of those given at a conference on Game Theoretic Models of Bargaining held at the University of Pittsburgh. There are two distinct reasons why the study of bargaining is of fundamental importance in economics. The first is (...) that many aspects of economic activity are directly influenced by bargaining between and among individuals, firms, and nations. The second is that bargaining occupies an important place in economic theory, since the 'pure bargaining problem' is at the opposite pole of economic phenomena from the case of 'perfect competition'. This volume is an outgrowth of the renewed interest in the strategic approach to the theory of bargaining and to the general theory of non-cooperative games. (shrink)

Standard practices in experimental economics arise for different reasons. The “no deception” rule comes from a cost-benefit tradeoff; other practices have to do with the uses to which economists put experiments. Because experiments are part of scientific conversations that mostly go on within disciplines, differences in standard practices between disciplines are likely to persist.

Testing economic propositions in laboratory experiments has proven a very fruitful research endeavor in recent years. This volume brings together the major contributors to experimental economics. The papers present their views on the way experiments should be done, on the power and limitations of the techniques, and on the areas in which experimentation could contribute substantially to our understanding of economic behavior. This book distills the main lessons from great experience in experimental work. It will be essential reading for all (...) who wish to follow experimental work or who wish to do such work themselves. (shrink)

We largely agree with Grimwade et al ’s1 conclusion that challenge trial participants may ethically be paid, including for risk. Here, we add further arguments, clarify some points from the perspective of economics and indicate areas where economists can support the development of a framework for ethically justifiable payment. Our arguments apply to carefully constructed and monitored controlled human infection model trials that have been appropriately reviewed and approved. Participants in medical studies perform a service. Outside the domain of research (...) participation, there is nearly universal agreement that workers providing a service should be compensated fairly, and that work involving more discomfort and risk should be compensated more generously. Accordingly, labour regulations impose floors, not caps on compensation. Caps, even if intended to protect against undue inducement, also raise concerns about illegal price-fixing that disadvantages workers. Such limits on payment for egg donors have successfully been challenged in court.i Moreover, caps on compensation may harm everyone at risk of infection, not just potential participants. Insufficient compensation may impede the recruitment of enough suitable subjects, for example, when representativeness of the subject sample is required. Delays in vaccine development not only prolong disruption of social, educational and economic activity but also lead to excess infections and deaths. Unlike paid CHIM participants, individuals exposed to such infection do not accept it voluntarily, are not compensated for it, and are unlikely to receive the level of medical supervision afforded to closely monitored CHIM participants. Payment caps can lead to attempts to circumvent the regulation. For example, many countries …. (shrink)

The peer commentaries on our Target Article, “Promoting Ethical Payment in Human Infection Challenge Studies,” offer a number of insights that will help advance the co...

The Physician Orders for Life-Sustaining Treatment Paradigm is designed to improve end-of-life care by converting patients' treatment preferences into medical orders that are transferable throughout the health care system. It was initially developed in Oregon, but is now implemented in multiple states with many others considering its use. An observational study was conducted in order to identify potential legal barriers to the implementation of a POLST Paradigm. Information was obtained from experts at state emergency medical services and long-term care organizations/agencies (...) in combination with a review of relevant state law. (shrink)

The Physician Orders for Life-Sustaining Treatment Paradigm is designed to improve end-of-life care by converting patients’ treatment preferences into medical orders that are transferable throughout the health care system. It was initially developed in Oregon, but is now implemented in multiple states with many others considering its use. Accordingly, an observational study was conducted in order to identify potential legal barriers to the implementation of a POLST Paradigm. Information was obtained from experts at state emergency medical services and long-term care (...) organizations/agencies in combination with a review of relevant state law. Legal analysis of survey responses and existing laws identified several potential state legal barriers to a POLST Paradigm implementation. The most potentially problematic barriers are detailed statutory specifications for out-of-hospital DNR protocols. Other potential barriers include limitations on the authority to consent to forgo life-sustaining treatments, medical preconditions, and witnessing requirements for out-of-hospital DNR protocols. (shrink)

To prepare for potential human infection challenge studies involving SARS-CoV-2, we convened a multidisciplinary working group to address ethical questions regarding whether and how much SAR...

The aim of this paper is to sketch a theory of justified belief. What I have in mind is an explanatory theory, one that explains in a general way why certain beliefs are counted as justified and others as unjustified. Unlike some traditional approaches, I do not try to prescribe standards for justification that differ from, or improve upon, our ordinary standards. I merely try to explicate the ordinary standards, which are, I believe, quite different from those of many classical, (...) e. g., ‘Cartesian’, accounts. (shrink)

This paper presents a partial analysis of perceptual knowledge, an analysis that will, I hope, lay a foundation for a general theory of knowing. Like an earlier theory I proposed, the envisaged theory would seek to explicate the concept of knowledge by reference to the causal processes that produce (or sustain) belief. Unlike the earlier theory, however, it would abandon the requirement that a knower's belief that p be causally connected with the fact, or state of affairs, that p.

A first year graduate student, Ann Dee Margulies, changed my research career in 1962 by challenging me to direct her in the isolation of recombination‐deficient mutants of Escherichia coli K‐12. She succeeded in isolating two mutants, which conjugated with donor strains and received the donor DNA, but could not recombine that DNA with their own chromosomes. Ann Dee showed that both mutants were much more sensitive to UV radiation than was the wild type. Furthermore, she showed that one of these (...) mutants carried a single mutation affecting both recombination and resistance. This work, published in 1965, was the first demonstration of the recA gene of E. coli. Subsequent work led to the discovery of many more recombination genes, the phenomenon of post replication‐recombination repair, the invention of the SOS hypothesis and the discovery of genes encoding proteins with similar primary structure and function in all major groups of organisms. This article honors the memory of Ann Dee. (shrink)

Knowledge of God takes the form of a debate between Alvin Plantinga and Michael Tooley. Plantinga opens the batting with a seventy-page laying out of his case ‘that theism has a significant epistemic virtue: if it is true, it is warranted; this is a virtue naturalism emphatically lacks’. Indeed, Plantinga argues that ‘if naturalism were true, there would be no such thing as knowledge’. It will be recalled [e.g. Plantinga and Plantinga ] that Plantinga's position is that warrant, understood (...) as whatever it is that needs to be added to true belief to …. (shrink)

I begin with some familiar conceptions of epistemic relativism. One kind of epistemic relativism is descriptive pluralism. This is the simple, non-normative thesis that many different communities, cultures, social networks, etc. endorse different epistemic systems (E-systems), i.e., different sets of norms, standards, or principles for forming beliefs and other doxastic states. Communities try to guide or regulate their members’ credence-forming habits in a variety of different, i.e., incompatible, ways. Although there may be considerable overlap across cultures in certain types of (...) epistemic norms (e.g., norms for perceptual belief), there are sharp differences across groups in other types of epistemic norms. (shrink)

How can intuitions be used to validate or invalidate a philosophical theory? An intuition about a case seems to be a basic evidential source for the truth of that intuition, i.e., for the truth of the claim that a particular example is or isn’t an instance of a philosophically interesting kind, concept, or predicate. A mental‐state type is a basic evidential source only if its tokens reliably indicate the truth of their contents. The best way to account for intuitions being (...) a basic evidential source is to interpret their subject matter in psychologistic terms. Intuitions provide evidence about the contents of the intuiter's concept, where “concept” is understood as a psychological structure. (shrink)

Many current programs for cognitive science sail under the banner of “embodied cognition.” These programs typically seek to distance themselves from standard cognitive science. The present proposal for a conception of embodied cognition is less radical than most, indeed, quite compatible with many versions of traditional cognitive science. Its rationale is based on two elements, each of which is theoretically plausible and empirically well-founded. The first element invokes the idea of “bodily formats,” i.e., representational codes primarily utilized in forming interoceptive (...) or directive representations of one’s bodily states and activities. The second element appeals to wideranging evidence that the brain reuses or redeploys cognitive processes having different original uses. When the redeployment theme is applied to bodily formats of representation, they jointly provide for the possibility that body-coded cognition is a very pervasive sector of cognition. (shrink)

The evaluation of arguments and argumentation is best understood epistemologically. Epistemic circularity is not formally defective but it may be epistemologically objectionable. Sorenson's doubts about the syntactic approach to circularity are endorsed with qualifications. One explanation of an argument's goodness is its ability to produce justified belief in its conclusion by means of justified belief in its premises, but matters are not so simple for interpersonal argumentation. Even when an argument's premises and conclusion are justified for a speaker, this justifiedness (...) may not be transmissible to every hearer. Still, an epistemic approaeh is instructive. Arguing in enthymemes can be legitimate, e.g., because enthymemes can help produce justified persuasion in an audience that supplies the missing premises. (shrink)

This chapter considers how imagination generates emotion. ‘Supposition-imagination’ (S-imagination) is distinguished from ‘enactment-imagination’ (E-imagination). The former kind of imagination involves entertaining or supposing various hypothetical scenarios; with the latter kind of imagination, one tries to create a kind of facsimile of a mental state. Thus, one might try to create a perception-like state as in visual imagination or motoric imagination. It is argued that this much richer form of imagination generates typical emotional reactions to fiction. Emotional reactions to fiction are (...) generated in several different ways, including a process in which we E-imagine being a hypothetical reader or observer of fact. (shrink)

“1950’li yıllarda dönemin büyük felsefecileri arasında dinsel inancı savunan bir kişi bile yoktu. 1990’lı yıllarda Yale’den UCLA’ya, Oxford’dan Heidelberg’e kadar birçok yerde insanın manevi yanını savunan ve geliştiren yüzlerce kitap yazılacak, sel olup akacaktı. Aradaki 40 yıllık süre zarfındaysa sadece ve sadece Alvin Plantinga vardı.” Kelly James Clark Tanrı’nın veya tanrıların varlığı sorusu felsefenin ezeli sorularından biri olagelmişse de Nietzsche’nin Tanrı’nın ölümünü ilan ettiği günden bu yana onu doğrularcasına yaşanan acılar, savaşlar, kötülükler bu konudaki tartışmaların sesini uzun süre bastırdı. (...) Ama özellikle yüzyılın ikinci yarısından sonra palazlanan analitik felsefede meydana gelen “metafiziğe dönüş”, dine yakınlık duyan, en azından dinle ilgilenen filozofların tekrar Yahudi-Hıristiyan ve İslam geleneklerinde anlaşıldığı şekliyle Tanrı’nın varlığına duyulan inancın gerekçelerini yeniden değerlendirmelerine, konuya yeni bir bakış ve araçlarla bakmalarına vesile oldu. Alvin Plantinga’nın bu kitabı, yayımlandığı tarihten itibaren “analitik din felsefesi” alanının da en önemli ve sarsıcı eserlerinden biri hâline geldi ve Tanrı’nın ölmediğini ilan etti. Anselmus’tan Hume’a, Kant ve pozitivistlerden John Mackie gibi modern ateologlara kadar felsefe geleneğiyle hesaplaşan Plantinga, bu abidevi çalışmasında ontolojik, kozmolojik ve teleolojik tanrı kanıtlamalarının eski ve yeni biçimlerinin çıkmazlarını, meziyetlerini ve sunduğu imkânları değerlendiriyor. Tanrı’nın varlığına duyulan inanç ile diğer insanların varlığına ve zihinlerine duyulan inanç arasındaki şaşırtıcı ve sarsıcı bağlantıyı ortaya koyuyor. (shrink)

Epistemology has always been concerned with mental states, especially doxastic states such as belief, suspension of judgment, and the like. A significant part of epistemology is the attempt to evaluate, appraise, or criticize alternative procedures for the formation of belief and other doxastic attitudes. In addressing itself to doxastic states, epistemology has usually employed our everyday mental concepts and language. Occasionally it has tried to systematize or precise these mental categories, e.g., by introducing the notion of subjective probabilities. But this (...) is a minor refinement in our intuitive notion of degrees of confidence. What epistemology has not done—at least 20th century analytic epistemology hasn’t done it—is to seek help from experimental psychology in choosing its doxastic categories. Analytic epistemology has generally assumed that doxastic descriptions generated by casual and introspective thought are adequate for its purposes. (shrink)

A common contemporary claim is the conjunction of metaphysical naturalism—the idea, roughly, that there is no such person as God or anything at all like God—with the view that our cognitive faculties have come to be by way of the processes to which contemporary evolutionary theory direct our attention. Call this view ‘N&E’. I’ve argued elsewhere that this view is incoherent or self-defeating in that anyone who accepts it has a defeater for R, the proposition that her cognitive faculties are (...) reliable, which then gives her a defeater for any proposition she believes, including, of course, N&E itself. The argument for, in turn, depends essentially on the proposition that P is low or inscrutable. To support, I divided N&E into mutually exclusive and jointly exhaustive subcases, arguing that in each subcase Si, P is low or inscrutable. I won’t repeat this argument here, but I do want to focus on a certain essential aspect of the argument for. (shrink)

A common contemporary claim is the conjunction of metaphysical naturalism—the idea, roughly, that there is no such person as God or anything at all like God—with the view that our cognitive faculties have come to be by way of the processes to which contemporary evolutionary theory direct our attention. Call this view ‘N&E’. I’ve argued elsewhere that this view is incoherent or self-defeating in that anyone who accepts it has a defeater for R, the proposition that her cognitive faculties are (...) reliable, which then gives her a defeater for any proposition she believes, including, of course, N&E itself. The argument for, in turn, depends essentially on the proposition that P is low or inscrutable. To support, I divided N&E into mutually exclusive and jointly exhaustive subcases, arguing that in each subcase Si, P is low or inscrutable. I won’t repeat this argument here, but I do want to focus on a certain essential aspect of the argument for. (shrink)

The question is: how should a theist think of justification or positive epistemic status? The answer I suggest is: a belief B has positive epistemic status for S only if S’s faculties are functioning properly (i.e., functioning in the way God intended them to) in producing B, and only if S’s cognitive environment is sufficiently similar to the one for which her faculties are designed; and under those conditions the more firmly S is inclined to accept B, the more positive (...) epistemic status it has for her. I conclude by making some qualifications and applications and exmaining some objections. (shrink)

Chapter 6 is an attempt to show that the Theory of Worldbound Individuals —i.e. the theory that any object exists in exactly one possible world—is false, and that there's no good reason to deny that objects exist in more than one world. First, arguments that attempt to show that a denial of TWI entails a contradiction fail, and the so‐called Problem of Transworld Identity is no problem at all. Second, TWI should be rejected because it entails that all of an (...) object's properties are essential to it. The defender of TWI may attempt to defend his view by adopting Counterpart Theory. I conclude by arguing that the Counterpart Theory is both semantically and metaphysically inadequate. (shrink)

I clarify the notion of necessity that I will be examining in the book. In the first section, I claim that the relevant notion of necessity is ‘broad logical necessity’, which I distinguish from causal necessity, unrevisability and a proposition being self‐evident or a priori. In the second section, I distinguish between modality de dicto and modality de re. An assertion of modality de dicto predicates a modal property of another dictum or proposition, while a claim of modality de re (...) asserts of an object that it possess a property either essentially or contingently. I conclude by examining the use of the de dicto/de re distinction in the works of Aristotle, St. Thomas Aquinas, G.E. Moore, and Norman Malcolm. (shrink)

I argue that each object has many essences. A property E is an essence of object x if and only if E is essential to x and in every possible world everything distinct from x has the complement of E essentially. I then elaborate on the nature of essences and examine the relationship between essences and proper names. My view is that John Stuart Mill was mistaken in his belief that proper names do not express properties. In fact, proper names (...) express essences and I make use of this fact in addressing the famous problem of Hesperus and Phosphorus. (shrink)

Epistemology needs a social branch to complement its traditional, ‘individualist’ branch. Like its individualist sister, social epistemology would be an evaluative enterprise. It would assess (actual and possible) social practices in terms of their propensities to promote or inhibit knowledge, where knowledge is understood in the sense of true belief. Social epistemology should examine the practices of many types of players, as well as technological and institutional structures: speakers, hearers, gate-keepers of communication (e.g., editors, publishers, referees), communication technologies and their (...) applications, and legal and economic arrangements that influence the epistemic quality of public speech. A mixture of analytical tools should be employed to assess practices in terms of their likely knowledge outcomes, tools that include Bayesian probability theory, economic theory, and empirical inquiry. (shrink)

A few comments may help set the record straight on the issues Braybrooke raises (or reraises). First, I concede that my treatment of the relation between resources and opportunity costs was inaccurate. Braybrooke is correct in saying that opportunity costs may rise while resources are also rising. By itself, however, this does not resolve the question of whether power is inversely related to opportunity cost. It may still be true that one's power goes down when opportunity cost rises, even if (...) one's (total) resources are rising. Specifically, one's power vis-a-vis e may go down precisely because the opportunity cost of getting e rises, even though one's total resources (and perhaps one's overall power) are rising. (shrink)

Recent findings regarding the cellular biology and immunology of BST‐2 (also known as tetherin) indicate that its function could be exploited as a universal replication inhibitor of enveloped respiratory viruses (e.g., influenza, respiratory syncytial virus, etc.). BST‐2 inhibits viral replication by preventing virus budding from the plasma membrane and by inducing an antiviral state in cells adjacent to infection via unique inflammatory signaling mechanisms. This review presents the first comprehensive summary of what is currently known about BST‐2 anti‐viral function against (...) respiratory viruses, how these viruses construct countermeasures to antagonize BST‐2, and how BST‐2 function might be targeted to develop therapies to treat respiratory virus infections. The authors address the current gaps in knowledge, including the need for mechanistic understanding of BST‐2 antagonism by respiratory viruses, that should be bridged to achieve that goal. (shrink)